- Lynn 1136 Purdue Avenue
- Lynn 1136 Purdue Owl
- Lynn 1136 Purdue University
- Lynn 1136 Purdue
- Purdue Lynn 1136
- Lynn 1136 Purdue Ave
Purdue Institute of Inflammation, Immunology and Infectious Disease. November 1, 2018. 3:30 PM - 5:00 PM. Jeff Bender presents the 5th annual COPPOC One Health Lecture titled, 'Antimicrobial Stewardship and One Health.' Bender is a professor in the School of Public Health and adjunct professor the College of. Using a Wireless Mic in a TIC site. To use a wireless microphone, you must be in a TIC site that has a wireless mic receiver. You may purchase your own wireless mic transmitter or use one in the room.
Purdue University, LYNN 1136. 625 Harrison St, West Lafayette, IN 47907. Topic: Design and synthesis of new antimicrobials for use as antibiotics. Guest Speaker: Miri Niedrauer, PhD candidate, Organic Chemistry. I am a graduate student at Purdue University, studying organic chemistry. About half of all IT staff working at Purdue work for ITaP. LYNN 1136 ) Allows students easier access to audio and video content. Fall 2010 – Technology Tools. Art In The Classroom. Fund Year Title Location Artists; 1991: Stolid Gazer: HEAV 128: Adam Henry: 2003: Intangible Series.
Retter Professor of Pharmacy
Phone:
Fax:
E-mail:
Lab website:
Specialization: Phase transformations, physical and chemical stability, water-solid interactions, amorphous systems and solid dispersions
Education
Bachelor of Pharmacy with Honors, University of Bath, UK, 1990
PhD, Pharmaceutical Technology, University of Bradford, UK, 1996
Post-doctoral Research Associate, University of Wisconsin-Madison 1996-1998
Associate Principal Scientist, AstraZeneca R&D, Mölndal, Sweden, 1998-2003
PhD, Pharmaceutical Technology, University of Bradford, UK, 1996
Post-doctoral Research Associate, University of Wisconsin-Madison 1996-1998
Associate Principal Scientist, AstraZeneca R&D, Mölndal, Sweden, 1998-2003
Lynn 1136 Purdue Avenue
Research
Our overall goal is to enhance the delivery, efficacy and safety of drugs. Supersaturation, absorption, crystallization and crystallization inhibition are important phenomena impacting the bioavailability of drugs. Amorphous solid dispersions, used to improve the oral delivery of poorly water-soluble drugs, are prepared by spray drying or hot melt extrusion, which are complex manufacturing operations. We are currently investigating the interplay between processing conditions and product performance for amorphous formulations. Pharmaceutical salt stability and excipient functionality are also key topics. More recently, we have been working on the preparation of individualized dosage forms using drop-on-demand printing. We are also interested in high resolution analytical techniques to explore bulk and surface characteristics.
Current Research Projects
1. Stabilization of amorphous solid dispersions against crystallizaton
2. 3D printing approaches
3. Miscibility in amorphous solid dispersions
4. Novel polymers to stabilize amorphous solids (collaboration with Professor K. Edgar, Virginia Tech)
5. Stabilization of supersaturated solutions
6. Improving amorphous solid dispersion drug loading
7. Spray drying and hot melt extrusion
8. Modification of surface properties for improved performance of powders
9. Disproportionation of pharmaceutical salts
10. Second harmonic generation for the characterization of trace crystallization. (collaboration with Professor G. Simpson, Chemistry, Purdue University)
Lab Members
Pradnya P. Bapat (Graduate Student)
Clara E. Correa Soto (Graduate Student)
Benedito R. De Alvarenga Jr. (Visiting Scholar)
Alexandru Deac (Graduate Student)
Van Tu Duong (Post-Doctoral Research Associate)
Chengzhe Gao (Post-Doctoral Research Associate)
Tze Ning Hiew (Post-Doctoral Research Associate)
Dana Moseson (Graduate Student)
Hanh Thuy Nguyen (Post-Doctoral Research Associate)
Andrew S. Parker (ChE Graduate Student)
Qingqing Qi (Post-Doctoral Research Associate)
Dishan D. Shah (Graduate Student)
Ruochen Yang (Graduate Student)
Clara E. Correa Soto (Graduate Student)
Benedito R. De Alvarenga Jr. (Visiting Scholar)
Alexandru Deac (Graduate Student)
Van Tu Duong (Post-Doctoral Research Associate)
Chengzhe Gao (Post-Doctoral Research Associate)
Tze Ning Hiew (Post-Doctoral Research Associate)
Dana Moseson (Graduate Student)
Hanh Thuy Nguyen (Post-Doctoral Research Associate)
Andrew S. Parker (ChE Graduate Student)
Qingqing Qi (Post-Doctoral Research Associate)
Dishan D. Shah (Graduate Student)
Ruochen Yang (Graduate Student)
Teaching
Honors and Credentials
- 2014 Chaney Faculty Scholar Award
- Fellow of the American Association of Pharmaceutical Scientists
- Fellow of the Royal Society of Chemistry
- University Faculty Scholar 2009-2014
- Entrepreneurial Leadership Academy Fellow 2008-2009
- AAPS Outstanding Manuscript in Pharmaceutical Analysis and Quality 2008
- AACP New Investigator Grant 2003
- AAPS New Investigator Award 2003
Representative Publications
Dening, T. J.; Zemlyanov, D.; Taylor, L. S. Application of an adsorption isotherm to explain incomplete drug release from ordered mesoporous silica materials under supersaturating conditions. Journal of Controlled Release 2019, 307, 186-199.
Dong, Y.; Novo, D. C.; Mosquera-Giraldo, L. I.; Taylor, L. S.; Edgar, K. J. Conjugation of bile esters to cellulose by olefin cross-metathesis: A strategy for accessing complex polysaccharide structures. Carbohydrate Polymers 2019, 221, 37-47.
Elkhabaz, A.; Sarkar, S.; Simpson, G. J.; Taylor, L. S. Characterization of Phase Transformations for Amorphous Solid Dispersions of a Weakly Basic Drug upon Dissolution in Biorelevant Media. Pharmaceutical Research 2019, 36, (12), 174.
Indulkar, A. S.; Gao, Y.; Raina, S. A.; Zhang, G. G. Z.; Taylor, L. S. Impact of Monomeric versus Micellar Surfactant and Surfactant–Polymer Interactions on Nucleation–Induction Times of Atazanavir from Supersaturated Solutions. Crystal Growth & Design 2019, 20, (1), 62-72.
Indulkar, A. S.; Lou, X.; Zhang, G. G. Z.; Taylor, L. S. Insights into the Dissolution Mechanism of Ritonavir–Copovidone Amorphous Solid Dispersions: Importance of Congruent Release for Enhanced Performance. Molecular Pharmaceutics 2019, 16, (3), 1327-1339.
Li, N.; Taylor, L. S. Microstructure formation for improved dissolution performance of lopinavir amorphous solid dispersions. Molecular Pharmaceutics 2019, 16, (4), 1751-1765.
Mauer, L. J.; Forny, L.; Meunier, V. D. M.; Taylor, L. S. Optimizing the Quality of Food Powder Products: The Challenges of Moisture-Mediated Phase Transformations. Annual Review of Food Science and Technology 2019, 10, 457-478.
Moseson, D. E.; Parker, A. S.; Gilpin, C. J.; Stewart, A. A.; Beaudoin, S. P.; Taylor, L. S. Dissolution of indomethacin crystals into a polymer melt: role of diffusion and fragmentation. Crystal Growth & Design 2019, 19, (6), 3315-3328.
Purohit, H. S.; Trasi, N. S.; Osterling, D. J.; Stolarik, D. F.; Jenkins, G. J.; Gao, W.; Zhang, G. G. Z.; Taylor, L. S. Assessing the impact of endogenously derived crystalline drug on the in vivo performance of amorphous formulations. Molecular Pharmaceutics 2019, 16, (8), 3617-3625.
Que, C.; Lou, X.; Zemlyanov, D. Y.; Mo, H.; Indulkar, A. S.; Gao, Y.; Zhang, G. G. Z.; Taylor, L. S. Insights into the Dissolution Behavior of Ledipasvir–Copovidone Amorphous Solid Dispersions: Role of Drug Loading and Intermolecular Interactions. Molecular Pharmaceutics 2019, 16, (12), 5054-5067.
Saboo, S.; Mugheirbi, N. A.; Zemlyanov, D. Y.; Kestur, U. S.; Taylor, L. S. Congruent release of drug and polymer: a “sweet spot” in the dissolution of amorphous solid dispersions. Journal of Controlled Release 2019, 298, 68-82.
Sherman, A. M.; Geiger, A. C.; Smith, C. J.; Taylor, L. S.; Hinds, J.; Stroud, P. A.; Simpson, G. J. Stochastic Differential Scanning Calorimetry by Nonlinear Optical Microscopy. Analytical Chemistry 2019, 92, (1), 1171-1178.
Trasi, N. S.; Bhujbal, S.; Zhou, Q. T.; Taylor, L. S. Amorphous solid dispersion formation via solvent granulation–A case study with ritonavir and lopinavir. International Journal of Pharmaceutics: X 2019, 1, 100035.
Tres, F.; Posada, M. M.; Hall, S. D.; Mohutsky, M. A.; Taylor, L. S. The Effect of Promiscuous Aggregation on in Vitro Drug Metabolism Assays. Pharmaceutical Research. 2019, 36, (12), 170.
Voelker, A. L.; Verbeek, G.; Taylor, L. S.; Mauer, L. J. Effects of emulsifiers on the moisture sorption and crystallization of amorphous sucrose lyophiles. Food Chemistry: X 2019, 3, 100050.
Thorat, A. A., Forny, L., Meunier, V., Taylor, L. S., and Mauer, L. J. (2018). Effects of Mono-, Di-, and Tri-saccharides on the Stability and Crystallization of Amorphous Sucrose. Journal of Food Science. 83(11):2827-2839.
Indulkar, A. S., Gao, Y., Raina, S. A., Zhang, G. G. Z., and Taylor, L. S. (2018). Crystallization from supersaturated solutions: Role of lecithin and composite simulated intestinal fluid. Pharmaceutical Research. 35(8):158.
Hsu, H., Taylor, L. S., and Harris, M. T. (2018) Impact of Additives on Heterogeneous Crystallization of Acetaminophen. International Journal of Chemical Engineering. 2018:1-7.
Wilson, V. Lou, X., Osterling, D. J., Stolarik, D. F., Jenkins, G., Gao, W., Zhang, G. G. Z., and Taylor, L. S. (2018). Relationship between amorphous solid dispersion In Vivo absorption and In Vitro dissolution: phase behavior during dissolution, speciation, and membrane mass transport. Journal of Controlled Release. 292:172-182.
Mosquera-Giraldo, L. I., Borca, C. H., Parker, A. S., Dong, Y., Edgar, K. J., Beaudoin, S. P., Slipchenko, L.V, and Taylor, L. S. (2018). Crystallization Inhibition Properties of Cellulose Esters and Ethers for a Group of Chemically Diverse Drugs - Experimental and Computational Insight. Biomacromolecules. 19(12):4593-4606.
Moseson, D. E., Mugheirbi, N. A., Stewart, A. A., and Taylor, L. S. (2018). Nanometer-Scale Residual Crystals in a Hot Melt Extruded Amorphous Solid Dispersion: Characterization by Transmission Electron Microscopy. Crystal Growth and Design. 18(12):7633-7640.
Moseson, D. E. and Taylor, L. S. (2018). The application of temperature-composition phase diagrams for hot melt extrusion processing of amorphous solid dispersions to prevent residual crystallinity.International Journal of Pharmaceutics. 553(1-2):454-466.
Patel, M. A., Luthra, S., Shamblin, S. L., Arora, K., Krzyzaniak, J. F., and Taylor, L. S. (2018). Assessing the risk of salt disproportionation using crystal structure and surface topography analysis. Crystal Growth and Design. 18(11):7027-7040.
Mugheirbi, N. A., Mosquera-Giraldo, L. I., Borca, , Slipchenko, L.V, and Taylor, L. S. (2018). Phase Behavior of Drug-Hydroxypropyl Methylcellulose Amorphous Solid Dispersions Produced from Various Solvent Systems: Mechanistic Understanding of the Role of Polymer using Experimental and Theoretical Methods.Molecular Pharmaceutics. 15(8):3236-3251.
Arca, H., C., Bi, V., Mosquera-Giraldo, L. I., Xu, D., Taylor, L. S., and Edgar, K. J. (2018). Pharmaceutical Applications of Cellulose Ethers and Cellulose Ether Esters. Biomacromolecules. 19(7):2351-2376.
Dening, T. J., and Taylor, L. S. (2018) Supersaturation Potential of Ordered Mesoporous Silica Delivery Systems. Part 1: Dissolution Performance and Drug Membrane Transport Rates. Molecular Pharmaceutics. 15(8):3489-3501.
Voelker, A., Miller, J., Running, C.A., Taylor, L. S. and Mauer, L. J. (2018). Chemical stability and reaction kinetics of two thiamine salts (thiamine mononitrate and thiamine chloride hydrochloride) in solution. Food Research International. 112:443-456.
Bhujbal, S.V., Zemlyanov, D.Y., Cavallaro, A., Mangal, S., Taylor, L. S. and Zhou, Q. T. (2018). Qualitative and Quantitative Characterization of Composition Heterogeneity on the Surface of Spray Dried Amorphous Solid Dispersion Particles by an Advanced Surface Analysis Platform with High Surface Sensitivity and Superior Spatial Resolution. Molecular Pharmaceutics. 15(5):2045-2053.
Mosquera-Giraldo, L. I., Li, N., Wilson, V. R., Nichols, B. L. B., Edgar, K. J., and Taylor, L. S. (2018). Influence of Polymer and Drug Loading on the Release Profile and Membrane Transport of Telaprevir. Molecular Pharmaceutics. 15(4):1700-1713.
Sugihara, H. and Taylor, L. S. (2018) Evaluation of Pazopanib Phase Behavior Following pH-Induced Supersaturation. Molecular Pharmaceutics. 15(4):1690-1699.
Patel, M. A., Luthra, S., Shamblin, S. L., Arora, K., Krzyzaniak, J. F., and Taylor, L. S. (2018).Effect of excipient properties, water activity, and water content on the disproportionation of a pharmaceutical salt. International Journal of Pharmaceutics. 546 (1-2): 226-234.
Tres, F., Posada, M. M., Hall, S. D., Mohutsky, M. A., and Taylor, L. S. (2018). Mechanistic Understanding of the Phase Behavior of Supersaturated Solutions of Poorly Water-Soluble Drugs. International Journal of Pharmaceutics. 543 (1-2):29-37.
Liu, S., Gao, C., Mosquera-Giraldo, L. I., Taylor, L. S., and Edgar, K. J. (2018) Selective Synthesis of Curdlan w-Carboxyamides by Staudinger Ylide Nucleophilic Ring-opening. Carbohydrate Polymers. 190:222-231.
Que, C., Gao, Y., Raina, S. A., Zhang, G. Z. Z., and Taylor, L. S. (2018) Paclitaxel Crystal Seeds with Different Intrinsic Properties and Their Impact on Dissolution of Paclitaxel-HPMCAS Amorphous Solid Dispersions. Crystal Growth and Design. 18(3):1548-1559.
Bhardwaj, V., Trasi, N. S., Zemlyanov, D. Y., and Taylor, L. S. (2018) Surface area normalized dissolution to study differences in itraconazole-copovidone solid dispersions prepared by spray-drying and hot melt extrusion. International Journal of Pharmaceutics. 540(1-2):106-119.
Purohit, H. S., Trasi, N. S., Sun, D. D., Chow, E. C. Y., Wen, H., Zhang, X., Gao, Y., and Taylor, L. S. (2018). Investigating the impact of drug crystallinity in amorphous tacrolimus capsules on pharmacokinetics and bioequivalence using discriminatory in vitro dissolution testing and PBPK modeling and simulation. Journal of Pharmaceutical Sciences.107(5):1330-1341.
Li, N., and Taylor, L.S. Tailoring supersaturation from amorphous solid dispersions. (2018) Journal of Controlled Release. 279:114-125.
Alin, J., Setiawan, N., Defrese, M., DiNunzio, J., Lau, H., Lupton, L., Xi, H., Su, Y., Nie, H., Hesse, N., Taylor, L. S., and Marsac, P. J. (2018). A novel approach for measuring room temperature enthalpy of mixing and associated solubility estimation of a drug in a polymer matrix.Polymer. 135(17):50-60.
Elkhabaz, A., Sarkar, S., Dinh, J. K., Simpson, G. J., and Taylor, L.S. (2018). Variation in the Supersaturation and Phase Behavior of Ezetimibe Amorphous Solid Dispersions Upon Dissolution in Different Biorelevant Media.Molecular Pharmaceutics. 15(1):193-206.
Tres, F., Hall, S. D., Mohutsky, M. A., and Taylor, L. S. (2018). Monitoring the Phase Behavior of Supersaturated Solutions of Poorly Water-Soluble Drugs Using Fluorescence Techniques. Journal of Pharmaceutical Sciences. 107(1):94-102.
Kalra, A., Luner, P., Taylor, L. S., Byrn, S. R., and Li, T. (2018). Gaining Thermodynamic Insight from Distinct Glass Formation Kinetics of Structurally Similar Organic Compounds. Journal of Pharmaceutical Sciences. 107(1):192-202.
Arca, H., C., Mosquera-Giraldo, L. I., Pereira, J. M. Sriranganathan, N., Taylor, L. S., Edgar, K. J. Rifampin Stability and Solution Concentration Enhancement through Amorphous Solid Dispersion in Cellulose ω-Carboxyalkanoate Matrices (2018). Journal of Pharmaceutical Sciences. 107(1):127-138.
Patel, M. A., Luthra, S., Shamblin, S. L., Arora, K., Krzyzaniak, J. F., and Taylor, L. S. (2018). Impact of solid-state form on the disproportionation of miconazole mesylate. Molecular Pharmaceutics. 15(1):40-52.
Winslow, C. J., Nichols, B. L. B, Novo, D. C. , Mosquera-Giraldo, L. I. , Taylor, L. S., Edgar, K. J., and Neilson, A. P. (2018). Cellulose-based amorphous solid dispersions enhance rifapentine delivery characteristics in vitro. Carbohydrate Polymers. 182(15):149-158.
Arca, H., C., Mosquera-Giraldo, L. I., Pereira, J. M. Sriranganathan, N., Taylor, L. S., Edgar, K. J. (2017). Rifampin Stability and Solution Concentration Enhancement through Amorphous Solid Dispersion in Cellulose ω-Carboxyalkanoate Matrices. Journal of Pharmaceutical Sciences. 107(1):127-138. http://dx.doi.org/10.1016/j.xphs.2017.05.036
Thorat, A. A., Forny, L., Meunier, V., Taylor, L. S., and Mauer, L. J. (2017) Effects of chloride and sulfate salts on the inhibition or promotion of sucrose crystallization in initially amorphous sucrose-salt blends. Journal of Agricultural and Food Chemistry. 65(51):11259-11272. http://dx.doi.org/10.1021/acs.jafc.7b04746
Tian, B., Gao, W., Tao, X., Tang, X., and Taylor, L. S. (2017) Impact of Polymers on the Melt Crystal Growth Rate of Indomethacin Polymorphs. Crystal Growth and Design. 17(12):6467-6476. http://dx.doi.org/10.1021/acs.cgd.7b01145
Mugheirbi, N. A., Marsac, P. J. and Taylor, L. S. (2017) Insights into Water-Induced Phase Separation in Itraconazole-hydroxypropylmethyl cellulose Spin Coated and Spray Dried Dispersions. Molecular Pharmaceutics. 14(12):4387-4402. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00499
Hate, S. S., Reutzel-Edens, S. M., and Taylor, L. S. (2017) Absorptive Dissolution Testing of Supersaturating Systems: Impact of Absorptive Sink Conditions on Solution Phase Behavior and Mass Transport. Molecular Pharmaceutics. 14(11):4052-4063. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00740
Purohit, H. S., and Taylor, L. S. (2017). Phase Behavior of Ritonavir Amorphous Solid Dispersions During Hydration and Dissolution. Pharmaceutical Research. 34(12):2842-2861. http://dx.doi.org/10.1007/s11095-017-2265-5
Arca, H., C., Mosquera-Giraldo, L. I., Dahal, D., Taylor, L. S., and Edgar, K. J. (2017). Multidrug, Anti-HIV Amorphous Solid Dispersions: Nature and Mechanisms of Impacts of Drugs on Each Other’s Solution Concentrations. Molecular Pharmaceutics. 14(11):3617-3627. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00203
Mugheirbi, N. A., O’Connel, P., Taylor, L. S., and Tajber, L. (2017) A comparative study on the performance of inert and functionalized spheres coated with solid dispersions made of two structurally related antifungal drugs. Molecular Pharmaceutics. 14(11):3718-3728. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00482
Correa-Soto, C., Trasi, N. S., Schmitt, P. D. Su, Y., Liu, Z., Variankaval, N., Marsac, P. J., Simpson, G. J., and Taylor, L. S. (2017). Second Harmonic Generation Microscopy as a Tool for the Early Detection of Crystallization in Spray Dried Dispersions. Journal of Pharmaceutical and Biomedical Analysis. 146:86-95. http://dx.doi.org/10.1016/j.jpba.2017.07.066
Xie, T., Gao, W., and Taylor, L. S. (2017). Impact of Eudragit EPO and Hydroxypropyl Methylcellulose on Drug Release Rate, Supersaturation, Precipitation Outcome and Redissolution Rate of Indomethacin Amorphous Solid Dispersions. International Journal of Pharmaceutics. 531(1):313-323. http://dx.doi.org/10.1016/j.ijpharm.2017.08.099
Lu, J., Ormes, J. D., Lowinger, M., Mann, A. K. P., Xu, W., Patel, S., Litster, J. D., and Taylor, L. S. (2017). Compositional Effect of Complex Biorelevant Media on the Crystallization Kinetics of an Active Pharmaceutical Ingredient. CrystEngComm. 19:4797-4806. http://dx.doi.org/10.1039/C7CE01128H
Saboo, S., and Taylor, L. S. (2017). Water-induced Phase Separation of Miconazole-Poly (Vinylpyrrolidone-Co-Vinyl Acetate) Amorphous Solid Dispersions: Insights with Confocal Fluorescence Microscopy. International Journal of Pharmaceutics. 529(1-2):654-666. http://dx.doi.org/10.1016/j.ijpharm.2017.07.034
Trasi, N. S., Purohit, H., and Taylor, L. S. (2017). Evaluation of the Crystallization Tendency of Commercially Available Amorphous Tacrolimus Formulations Exposed to Different Stress Conditions. Pharmaceutical Research. 34(10):2142-2155. http://dx.doi.org/10.1007/s11095-017-2221-4
Arioglu-Tuncil, S., Bhardwaj, V., Taylor, L. S. and Mauer, L. J. (2017). The Crystallization Inhibitor Properties of Different Polymers in Thiamine Chloride Hydrochloride Amorphous Solid Dispersions. Food Research International. 99(1):263-374. http://dx.doi.org/10.1016/j.foodres.2017.05.021
Indulkar, A. S., Waters, J. E., Mo, H., Gao, Y., Raina, S. A., Zhang, G. G. Z., and Taylor, L. S. (2017). Origin of Nanodroplet Formation upon Dissolution of an Amorphous Solid Dispersion: A Mechanistic Isotope Scrambling Study. Journal of Pharmaceutical Sciences. 106(8):1998-2008. http://dx.doi.org/10.1016/j.xphs.2017.04.015
Kalra, A., Tishmack, P., Lubach, J. W., Munson, E., Taylor, L. S., Byrn, S. R., and Li, T. (2017). Impact of Supramolecular Aggregation on the Crystallization Kinetics of Organic Compounds from the Supercooled Liquid State. Molecular Pharmaceutics. 14(6):2126–2137. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00245
Lu, J., Ormes, J. D., Lowinger, M., Mann, A. K. P., Xu, W., Patel, S., Litster, J. D., and Taylor, L. S. (2017). Impact of Bile Salts on Solution Crystal Growth Rate and Residual Supersaturation of an Active Pharmaceutical Ingredient. Crystal Growth and Design. 17(6):3528–3537. http://dx.doi.org/10.1021/acs.cgd.7b00464
Purohit, H.S., Ormes, J. D., Saboo, S., Su, Y., Lamm, M. S., Mann, A. K. P., and Taylor, L. S. (2017). Insights into Nano- and Micron-scale Phase Separation in Amorphous Solid Dispersions using Fluorescence-based Techniques in Combination with Solid State Nuclear Magnetic Resonance Spectroscopy. Pharmaceutical Research. 34(7):1364-1377. http://dx.doi.org/10.1007/s11095-017-2145-z
Li, N., Gilpin, C. J. and Taylor, L. S. (2017) Understanding the impact of water on the miscibility and microstructure of amorphous solid dispersions – An AFM/LCR and TEM/EDX study. Molecular Pharmaceutics. 14(5):1691–1705. http://dx.doi.org/10.1021/acs.molpharmaceut.6b01151
Dong, Y., Mosquera-Giraldo, L.I., Taylor, L.S., and Edgar, K. J. (2017). Tandem Modification of Amphiphilic Cellulose Ethers for Amorphous Solid Dispersion via Olefin Cross-metathesis and Thiol-Michael Addition. Polymer Chemistry. 8:3129-3139. http://dx.doi.org/10.1039/C7PY00228A
Icten, E., Purohit, H. S., Wallace, C., Giridhar, A., Taylor, L. S., Nagy, Z. K., Reklaitis, G. V. (2017). Dropwise Additive Manufacturing of Pharmaceutical Products for Amorphous and Self Emulsifying Drug Delivery Systems. International Journal of Pharmaceutics. 524(1-2):424-432. http://dx.doi.org/10.1016/j.ijpharm.2017.04.003.
Indulkar, A. S., Mo, H., Gao, Y., Raina, S. A., Zhang, G. G. Z., and Taylor, L. S. (2017). Impact of micellar surfactant on supersaturation and insight into solubilization mechanisms in supersaturated solutions. Pharmaceutical Research. 34(6):1276-1296. http://dx.doi.org/10.1007/s11095-017-2144-0
Lu, J., Ormes, J. D., Lowinger, M., Mann, A. K. P., Xu, W., Litster, J. D., and Taylor, L. S. (2017). Maintaining Supersaturation of Active Pharmaceutical Ingredient Solutions with Biologically Relevant Bile Salts. Crystal Growth and Design. 17(5):2782–2791. http://dx.doi.org/10.1021/acs.cgd.7b00237
Thorat, A., Marrs, K. N., Ghorab, M. K., Meunier, V., Forny, L., Taylor, L. S, and Mauer, L. J. (2017). Moisture-Mediated Interactions between Amorphous Maltodextrins and Crystalline Fructose. Journal of Food Science. 82(5):1142–1156. http://dx.doi.org/10.1111/1750-3841.13676
Lu, J., Ormes, J. D., Lowinger, M., Xu, W., Mitra, A., Mann, A. K. P., Litster, J. D., and Taylor, L. S. (2017). Impact of Endogenous Bile Salts on the Thermodynamics of Supersaturated Active Pharmaceutical Ingredient Solutions. Crystal Growth and Design. 17(3):1264-1275. http://dx.doi.org/10.1021/acs.cgd.6b01664
Arca, H.C., Mosquera-Giraldo, L.I., Taylor, L.S., and Edgar, K. J. (2017). Synthesis and characterization of alkyl cellulose ω-carboxyesters for amorphous solid dispersion. Cellulose. 24:609-625. http://dx.doi.org/10.1007/s10570-016-1156-y
Nie, H., Xu, W., Taylor, L. S., Marsac, P. J., and Byrn, S. R. (2017). Crystalline solid dispersion-a strategy to slowdown salt disproportionation in solid state formulations during storage and wet granulation. International Journal of Pharmaceutics. 517(1-2):203-215. http://dx.doi.org/10.1016/j.ijpharm.2016.12.014
Sato, T. and Taylor, L. S. (2017). Acceleration of the crystal growth rate of low molecular weight organic compounds in supercooled liquids in the presence of polyhydroxybutylate. CrystEngComm. 19:80-87. http://dx.doi.org/10.1039/C6CE02177H
Gilley, A. D., Arca, H. C., Nichols, B. L. B., Mosquera-Giraldo, L. I., Taylor, L. S., Edgar, K. J., Neilson, A. P. (2107). Novel Cellulose-Based Amorphous Solid Dispersions Enhance Quercetin Solution Concentrations In Vitro. Carbohydrate Polymers. 157:86-93. http://dx.doi.org/10.1016/j.carbpol.2016.09.067
Lynn 1136 Purdue Owl
Xie, T., and Taylor, L. S. (2017). Effect of Temperature and Moisture on the Physical Stability of Binary and Ternary Amorphous Solid Dispersions of Celecoxib. Journal of Pharmaceutical Sciences. 106(1):100-110. http://dx.doi.org/10.1016/j.xphs.2016.06.017
Trasi, N. S., Purohit, H. S., Wen, H., Sun, D. D., and Lynne S. Taylor (2017). Non-sink dissolution behavior and solubility limit of commercial tacrolimus amorphous formulations. Journal of Pharmaceutical Sciences. 106(1):264-272. http://dx.doi.org/10.1016/j.xphs.2016.09.016
![Lynn 1136 Purdue Lynn 1136 Purdue](https://images.nap.edu/books/9824/gif/453.gif)
Taylor, L. S., Rantanen, J., Paradkar, A., Kawashima, Y., and Zhang, J. (2017). Professor Peter York- A distinguished career in powders, processing and particle design. Journal of Pharmaceutical Sciences. 106(1):2-4. http://dx.doi.org/10.1016/j.xphs.2016.09.006
Li, N., Mosquera-Giraldo, L. I., Borca, C. H., Ormes, J. D., Lowinger, M. Higgins, J. D., Slipchenko, L.V., and Taylor, L. S. (2016). A Comparison of the Crystallization Inhibition Properties of Bile Salts. Crystal Growth and Design. 16(12):7286-7300.
Tian, B., Tang, X., and Taylor, L. S. (2016). Investigating the Correlation between Miscibility and Physical Stability of Amorphous Solid Dispersions Using Fluorescence-based Techniques.Molecular Pharmaceutics. 13(11):3988-4000.
Mosquera-Giraldo, L. I., Borca, C. H., Meng, X., Edgar, K. J., Slipchenko, L.V, and Taylor, L. S. (2016). Mechanistic Design of Chemically Diverse Polymers with Applications in Oral Drug Delivery. Biomacromolecules. 17(11):3659-3671.
Nie, H., Su, Y., Zhang, M., Song, Y., Leone, A., Taylor, L.S., Marsac, P. J., Li, T., and Byrn, S. R. (2016). Solid-State Spectroscopic Investigation of Molecular Interactions between Clofazimine and Hypromellose Phthalate in Amorphous Solid Dispersions. Molecular Pharmaceutics. 13(11):3964-3975.
Lu, M. and Taylor, L. S. (2016). Vemurafenib: A Tetramorphic System Displaying Concomitant Crystallization from the Supercooled Liquid.Crystal Growth and Design. 16(10):6033-6042.
Nie, H., Xu, W., Ren, J., Taylor, L. S., Marsac, P. J., John, C. T., and Byrn, S. R. (2016). Impact of Metallic Stearates on Disproportionation of Hydrochloride Salts of Weak Bases in Solid-State Formulations. Molecular Pharmaceutics. 13(10):3541-3552.
Dong, Y., Mosquera-Giraldo, L. I, Troutman, J., Skogstad, B., Taylor, L. S. and Edgar, K. J. (2016). Amphiphilic Hydroxyalkyl Cellulose Derivatives for Amorphous Solid Dispersion Prepared by Olefin Cross-Metathesis.Polymer Chemistry. 7:4953-4963.
Sun, D. D., Wen, H. and Taylor, L. S. (2016). Non-sink dissolution conditions for predicting product quality and in vivo performance of supersaturating drug delivery systems. Journal of Pharmaceutical Sciences. 105(9):2477-2488.
Sato, T. and Taylor, L. S. (2015). Chiral Discrimination by a Cellulose Polymer: Differential Crystallization Inhibition of Enantiomers in Amorphous Dispersions.CrystEngComm. 17:5046-5053.
Schmitt, P. D., Trasi, N. S., Taylor, L. S. and Simpson, G. S. Finding the Needle in the Haystack – Characterization of Trace Crystallinity in a Commercial Formulation of Paclitaxel Protein-Bound Particles by Raman Spectroscopy Enabled by Second Harmonic Generation Microscopy. (2015) Molecular Pharmaceutics. 12(7):2378-2383.
Indulkar, A. S., Gao, Y., Raina, S. A., Zhang, G. G. Z., and Taylor, L. S. (2016). Exploiting the phenomenon of liquid-liquid phase separation for enhanced and sustained membrane transport of a poorly water soluble drug.Molecular Pharmaceutics. 13(6):2059-2069.
Schram, C. J., Smyth, R. J., Taylor, L. S. and Beaudoin, S. P. (2016). Understanding Crystal Growth Kinetics in the Absence and Presence of a Polymer Using a Rotating Disk Apparatus.Crystal Growth and Design. 16(5):2640-2645.
Li, N., Ormes, J. D. and Taylor, L. S. (2016). Leaching of Lopinavir Amorphous Solid Dispersions in Acidic Media. Pharmaceutical Research. 33(7):1723-1735.
Taylor, L. S. and Zhang, G. G. Z. (2016) Physical Chemistry of Supersaturated Solutions and Implications for Oral Absorption. Advanced Drug Delivery Reviews. 101:122-142.
Alhalaweh, A., Bergström, C. A. S. and Taylor, L. S. (2016). Compromised in vitro dissolution and membrane transport of multidrug amorphous formulations. Journal of Controlled Release.229:172-182
Jackson, M. J., Kestur, U. S., Hussain, M. A., and Taylor, L. S. (2016). Characterization of Highly Supersaturated Danazol Solutions – Impact of Polymers on Solution Properties and Phase Transitions.Pharmaceutical Research. 33(5):1276-1288.
Li., N. and Taylor, L. S. (2016). Nanoscale Infrared, Thermal, and Mechanical Characterization of Telaprevir-Polymer Miscibility in Amorphous Solid Dispersions Prepared by Solvent Evaporation.Molecular Pharmaceutics. 13(3):1123-1136.
Schram, C. J., Beaudoin, S. P. and Taylor, L. S. (2016). Polymer Inhibition of Crystal Growth by Surface Poisoning.Crystal Growth and Design. 16(4):2094-2103.
Xie, T., and Taylor, L. S. (2016). Improved Release of Celexocib from High Drug Loading Amorphous Solid Dispersions Formulated with Polyacrylic Acid and Cellulose Derivatives.Molecular Pharmaceutics.13(3):873-884.
Almeida e Sousa, L., Reutzel-Edens, S. M., Stephenson, G. A. and Taylor, L. S. (2016). Supersaturation Potential of Salt, Co-Crystal and Amorphous Forms of a Model Weak Base. Crystal Growth and Design. 16(2):737-748.
Dong, Y., Mosquera-Giraldo, L. I., Taylor, L. S. and Edgar, K. J. (2016). Design of Functionalized Cellulose Ethers for Amorphous Solid Dispersion via Olefin Cross-Metathesis. Biomacromolecules. 17(2):454-465.
Jackson, M. J., Kestur, U. S., Hussain, M. A., and Taylor, L. S. (2016). Dissolution of Danazol Amorphous Solid Dispersions: Supersaturation and Phase Behavior as a Function of Drug Loading and Polymer Type. Molecular Pharmaceutics. 13(1):223-231.
Xie, T., and Vuescan 9 5 28 – scanner software with advanced features. Taylor, L. S. (2016). Dissolution Performance of High Drug Loading Celecoxib Amorphous Solid Dispersions Formulated with Polymer Combinations.Pharmaceutical Research. 33(3):739-750.
Nie, H., Liu, Z., Marks, B. C., Taylor, L. S., Byrn, S. R. and Marsac, P. J. (2016). Analytical Approaches to Investigate Salt Disproportionation in Tablet Matrices by Raman Spectroscopy and Raman Mapping. Journal of Pharmaceutical and Biomedical Analysis. 118:328-337
Allan, M., Taylor, L. S. and Mauer, L. J. (2016). Common-Ion Effects on the Deliquescence Lowering of Crystalline Ingredient Blends.Food Chemistry. 195:2-10.
Li, N., Taylor, L. S. and Mauer, L. J. (2016). Heat Transport Model for the Deliquescence Kinetics of Crystalline Ingredients and Mixtures.Journal of Food Engineering. 169:298-308.
Nie, H., Mo, H., Zhang, M., Song, Y., Fang, K., Taylor, L. S., Li, T. and. Byrn, S. R. (2015). Investigating the interaction pattern and structural elements of a drug-polymer complex at the molecular level.Molecular Pharmaceutics. 12(7)2459-2468.
![Lynn 1136 Purdue Lynn 1136 Purdue](https://vet.purdue.edu/news/wp-content/uploads/2019/11/20191105_132908_Lahr_and_IVSA_sm-1024x767.jpg)
Trasi, N. S. and Taylor, L. S. (2015). Thermodynamics of Highly Supersaturated Aqueous Solutions of Poorly Water Soluble Drugs – Impact of a Second Drug on the Solution Phase Behavior and Implications for Combination Products. Journal of Pharmaceutical Sciences. 104(8):2583-2593.
Lynn 1136 Purdue University
Indulkar, A., Box, K. J., Taylor, R., Ruiz, R., and Taylor, L. S. (2015). pH-Dependent Liquid-Liquid Phase Separation of Highly Supersaturated Solutions of Weakly Basic Drugs.Molecular Pharmaceutics. 12(7):2365-2377.
Purohit, H. S. and Taylor, L. S. Phase Separation Kinetics in Amorphous Solid Dispersions Upon Exposure to Water.(2015) Molecular Pharmaceutics. 12(5):1623-1635.
Chen, J., Mosquera-Giraldo L., Ormes, J. D., Higgins, J. D. and Taylor, L. S. (2015). Bile Salts as Crystallization Inhibitors of Supersaturated Solutions of Poorly Water-Soluble Compounds. Crystal Growth and Design. 15(6):2593-2597.
Raina, S. A., Van Eerdenbrug, B., Alonzo, D. E., Mo, H., Zhang, G. G. Z., Gao, Y. and Taylor, L. S. (2015). Trends in the Precipitation and Crystallization Behavior of Supersaturated Aqueous Solutions of Poorly Water Soluble Drugs Assessed using Synchrotron Radiation.Journal of Pharmaceutical Sciences. 104(6):1981-1992.
Içten, E., Giridhar, A., Taylor, L. S., Nagy, Z. K., Reklaitis, G. V. (2015). Dropwise Additive Manufacturing of Pharmaceutical Products for Melt-Based Dosage Forms.Journal of Pharmaceutical Sciences. 104(5):1641-1649.
Toth, S., Schmitt, P. D., Snyder, G. R., Trasi, N. S., George, I. A., Taylor, L. S. and Simpson, G. J. (2015) Ab Initio Prediction of the Diversity of Second Harmonic Generation from Pharmaceutically Relevant Materials. Crystal Growth Design. 15(2):581-586.
Chen, J., Ormes, J. D., Higgins, J. D. and Taylor, L. S. (2015) Impact of Surfactants on the Crystallization of Aqueous Suspensions of Celecoxib Amorphous Solid Dispersion Spray Dried Particles. Molecular Pharmaceutics. 12(2):533-541.
Trasi, N. S., Abbou-Oucherif, K., Litster, J. D. and Taylor, L. S. (2015) Evaluating the Influence of Polymers on Nucleation and Growth in Supersaturated Solutions of Acetaminophen.CrystEngComm. 17:1242-1248.
Mosquera-Giraldo L., and Taylor, L. S. (2015) Glass-Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Telaprevir. (2015) Molecular Pharmaceutics. 12(2):496-501.
Lynn 1136 Purdue
Almeida e Sousa, L., Reutzel-Edens, S. M., Stephenson, G. A. and Taylor, L. S. (2015). Assessment of the Amorphous “Solubility” of a Group of Diverse Drugs Using New Experimental and Theoretical Approaches.Molecular Pharmaceutics. 12(2):484-495.
Purdue Lynn 1136
Hsieh, Y-L., and Taylor, L. S. (2015). Salt Stability - Effect of Particle Size, Relative Humidity, Temperature and Composition on Salt to Free Base Conversion.Pharmaceutical. Research. 32(2):549-561.
Schram, C. J., Beaudoin, S. P. and Taylor, L. S. (2015). Impact of Polymer Conformation on the Crystal Growth Inhibition of a Poorly Water Soluble Drug in Aqueous Solution.Langmuir. 31(1):171-179.
Hsu, H-Y, Adigun, O. O., Taylor, L. S., Murad, S. and Harris, M. T. (2015). Impact of Surface Chemistry on Crystallization of Acetaminophen.Chemical Engineering Science. 126:1-9.
Lipasek, R.A., Li, N., Taylor, L. S. and Mauer, L. J. (2015) Effect of temperature and initial moisture content on the chemical stability and color change of various forms of vitamin C.International Journal of Food Properties. 18(4):862-879.
Lynn 1136 Purdue Ave
5th annual Purdue Veterinary Medicine Coppoc One Health Lecture
Purdue Institute of Inflammation, Immunology and Infectious Disease
3:30 PM - 5:00 PM
Description
Dr. Jeff Bender presents the 5th annual COPPOC One Health Lecture titled, 'Antimicrobial Stewardship and One Health.' Dr. Bender is a professor in the School of Public Health and adjunct professor the College of Veterinary Medicine at the University of Minnesota. He is currently the director for the USAID funded One Health Workforce Project, a workforce development program focused on preventing, detecting, ad responding to emerging pandemic threats. In addition, he is a co-director for the NIOSH funded Upper Midwest Agriculture Safety and Health Center (UMASH), a center focused on improving the health of agriculture workers and their families. His primary teaching and research interests include infection prevention, disease surveillance, emerging zoonotic diseases, occupation safety , food safety, and antimicrobial resistance.
The COPPOC One Health Lecture was established in 2014 to provide an annual campus-wider lectureship that focuses on the symbiotic relationship between veterinary and human medicine and its world-wide impact.
Contact Details
- Erin Lane
- [email protected]
- 765-496-3487